Research indicates that hydrogen sulfide – a gas created naturally in the body and released when someone passes gas – may offer a way to shield the brain from Alzheimer’s disease.
A new study from Johns Hopkins Medicine suggests that hydrogen sulfide could protect aging brain cells from damage, potentially slowing down cognitive decline. In the United States, around 500,000 people are diagnosed with Alzheimer’s disease annually.
A new study in The Proceedings of the National Academy of Sciences suggests that decreasing levels of hydrogen sulfide could lead to long-term neurological problems.
Researchers have found that hydrogen sulfide helps brain cells communicate. As we get older, our bodies make less of this compound, which may make brain cells more susceptible to damage.
Researchers studied how this treatment would work by using mice that were genetically engineered to have symptoms similar to Alzheimer’s disease. These mice were given a substance called NaGYY, which releases hydrogen sulfide and spreads it slowly through their bodies.
After receiving treatment for 12 weeks, mice were tested on their thinking and movement skills. The treated mice demonstrated a 50% increase in both memory and physical abilities when compared to those who didn’t receive treatment.
The mice treated with the hydrogen sulfide compound showed more activity and improved memory skills, according to researchers.
The research team found that hydrogen sulfide may be able to reverse some of the behavioral effects of Alzheimer’s disease.
Why hydrogen sulfide matters
Okay, so apparently our bodies actually make a little bit of hydrogen sulfide – it’s not all bad stuff! It’s part of how things run smoothly inside us. There’s this enzyme, called glycogen synthase kinase beta, and it’s like the main controller, keeping the hydrogen sulfide levels just right. It’s kinda like balancing the stats on my character – get it wrong, and things go haywire!
If hydrogen sulfide levels decrease, an enzyme can attach too strongly to a protein called Tau. This strong binding causes Tau to clump inside nerve cells, disrupting communication and ultimately causing the cells to die.
The researchers explained that this causes thinking skills, memory, and movement to gradually worsen and eventually disappear.
Research indicates that the amount of hydrogen sulfide varies in flatulence, and some studies suggest women’s gas contains more of this compound than men’s.
What this could mean for future treatments
Although the research was done using mice, scientists believe the findings could lead to new medications that use hydrogen sulfide in a carefully managed manner.
Instead of just letting the body produce hydrogen sulfide naturally, future Alzheimer’s treatments might focus on boosting its levels to help prevent or even undo brain damage.
The researchers noted that more research is necessary to confirm these results are both safe and work well in people.
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2025-12-15 19:50