Beyond Species Barriers: Predicting Antibiotic Resistance with Genomic Models
![MiniRocket and Global Pooling exhibit contrasting performance based on phylogenetic distance, with MiniRocket maintaining accuracy across increasing distances on validation sets while Global Pooling excels on unseen test sets, demonstrating that antibiotic resistance mechanisms-rather than phylogenetic relatedness alone-are the primary determinants of predictive power in assessing ampicillin resistance, a finding consistently observed across replicate analyses and further substantiated by metrics such as Matthews correlation coefficient [latex] MCC [/latex].](https://arxiv.org/html/2603.11141v1/figures/ampicillin_v1-1_phylogenetic_distance.png)
New research reveals that the key to accurately forecasting antibiotic resistance across different bacteria lies in how genomic information is analyzed, matching the method to the underlying genetic mechanisms.




![The equilibrium mean control [latex]\bar{D}^{1}(t)[/latex] is demonstrably affected by signal precision [latex]p[/latex], exhibiting a heightened incentive for belief manipulation when precision is low due to sluggish opponent posteriors, and converging towards a perfect-information benchmark as [latex]p[/latex] approaches infinity.](https://arxiv.org/html/2603.12140v1/x3.png)

